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Nat Genet. 2013 Dec;45(12):1431-8. doi: 10.1038/ng.2811. Epub 2013 Oct 27.

Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars.

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1] Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, China. [2] Biodynamic Optical Imaging Center (BIOPIC), Peking-Tsinghua Center for Life Sciences and School of Life Sciences, Peking University, Beijing, China. [3].


We report the sequencing at 131× coverage, de novo assembly and analyses of the genome of a female Tibetan wild boar. We also resequenced the whole genomes of 30 Tibetan wild boars from six major distributed locations and 18 geographically related pigs in China. We characterized genetic diversity, population structure and patterns of evolution. We searched for genomic regions under selection, which includes genes that are involved in hypoxia, olfaction, energy metabolism and drug response. Comparing the genome of Tibetan wild boar with those of neighboring Chinese domestic pigs further showed the impact of thousands of years of artificial selection and different signatures of selection in wild boar and domestic pig. We also report genetic adaptations in Tibetan wild boar that are associated with high altitudes and characterize the genetic basis of increased salivation in domestic pig.

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