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Nat Neurosci. 2013 Dec;16(12):1734-6. doi: 10.1038/nn.3576. Epub 2013 Oct 27.

Cerebellar Purkinje cell activity drives motor learning.

Author information

1
1] Department of Neurobiology, Stanford School of Medicine, Stanford, California, USA. [2] Department of Molecular and Cellular Physiology, Stanford School of Medicine, Stanford, California, USA. [3].

Abstract

The climbing fiber input to the cerebellar cortex is thought to provide instructive signals that drive the induction of motor skill learning. We found that optogenetic activation of Purkinje cells, the sole output neurons of the cerebellar cortex, can also drive motor learning in mice. This dual control over the induction of learning by climbing fibers and Purkinje cells can expand the learning capacity of motor circuits.

PMID:
24162651
PMCID:
PMC3966616
DOI:
10.1038/nn.3576
[Indexed for MEDLINE]
Free PMC Article
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