Send to

Choose Destination
See comment in PubMed Commons below
J Neurosurg Pediatr. 2014 Jan;13(1):62-7. doi: 10.3171/2013.9.PEDS13159. Epub 2013 Oct 25.

Angiography-negative primary angiitis of the central nervous system in childhood.

Author information

  • 1Department of Neurosurgery & Brain Repair, Division of Pediatric Neurosurgery, Morsani College of Medicine, University of South Florida, Tampa, Florida.


Childhood primary angiitis of the CNS is a recently characterized, potentially reversible disease process. A favorable outcome requires early diagnosis and appropriate treatment. The histological findings of childhood primary angiitis of the CNS are characterized by a lymphocytic, nongranulomatous vasculitis. This disorder can lead to neurological deficits, seizures, and strokes. Laboratory and radiographic investigation are part of the evaluation, but are often nonspecific. Conventional angiography can fail to show any abnormality, and biopsy may ultimately be required for diagnosis. Although there can be significant rates of morbidity and mortality if untreated, patients who receive appropriate therapy can experience excellent outcomes, and in many cases will demonstrate near-complete or total clinical and radiographic resolution. The case of a previously healthy 13-year-old girl with new-onset generalized tonic-clonic seizures is presented, with a review of the literature.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center