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Methods Mol Biol. 2014;1087:197-206. doi: 10.1007/978-1-62703-670-2_16.

Determination of HIV-1 co-receptor usage.

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1
Viral Evolution and Transmission Unit, Department of Immunology, Transplant, and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

Abstract

Human immunodeficiency virus type I (HIV-1) infects target cells through interaction with the CD4 molecule and chemokine receptors, mainly the β-chemokine receptor 5 (CCR5) and the α-chemokine receptor 4 (CXCR4). Viral isolates can be phenotypically classified based on the co-receptor they utilize to infect target cells. In this chapter, methods to determine the co-receptor usage of HIV-1 variants are described.

PMID:
24158824
DOI:
10.1007/978-1-62703-670-2_16
[Indexed for MEDLINE]
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