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Eur J Pharmacol. 2014 Jan 5;722:172-9. doi: 10.1016/j.ejphar.2013.09.071. Epub 2013 Oct 21.

Anticipatory nausea and vomiting due to chemotherapy.

Author information

1
University of Rochester Medical Center, Behavioral Medicine Unit, 265 Crittenden Blvd, Box 420658, Rochester, NY 14642, United States. Electronic address: Charles_kamen@urmc.rochester.edu.
2
University of Rochester Medical Center, Behavioral Medicine Unit, 265 Crittenden Blvd, Box 420658, Rochester, NY 14642, United States.

Abstract

As a specific variation of chemotherapy-induced nausea and vomiting, anticipatory nausea and vomiting (ANV) appears particularly linked to psychological processes. The three predominant factors related to ANV are classical conditioning; demographic and treatment-related factors; and anxiety or negative expectancies. Laboratory models have provided some support for these underlying mechanisms for ANV. ANV may be treated with medical or pharmacological interventions, including benzodiazepines and other psychotropic medications. However, behavioral treatments, including systematic desensitization, remain first line options for addressing ANV. Some complementary treatment approaches have shown promise in reducing ANV symptoms. Additional research into these approaches is needed. This review will address the underlying models of ANV and provide a discussion of these various treatment options.

KEYWORDS:

Anticipatory nausea and vomiting; Behavioral treatments; Cancer; Nausea; Vomiting

PMID:
24157982
PMCID:
PMC3880638
DOI:
10.1016/j.ejphar.2013.09.071
[Indexed for MEDLINE]
Free PMC Article

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