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AIDS. 2013 Sep 10;27(14):2309-12. doi: 10.1097/QAD.0b013e3283632e0c.

Characterization of CRF56_cpx, a new circulating B/CRF02/G recombinant form identified in MSM in France.

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aLaboratoire associé au CNR du VIH, hôpital Ch. Nicolle, CHU de Rouen bGRAM EA 2656, Faculté de Médecine-Pharmacie, Université de Rouen, Rouen, France cComputational and Evolutionary Biology research group, Faculty of Life Science, University of Manchester, Manchester, UK dAssistance Publique - Hopitaux de Paris, Groupe Hospitalier Bichat Claude Bernard, Service de Virologie eAssistance Publique - Hopitaux de Paris, Groupe Hospitalier Saint Louis, Service de Virologie, fAssistance Publique - Hopitaux de Paris, Groupe Hospitalier Pitié Salpêtrière, Service de Virologie, Paris, France.


Several B/CRF02_AG Unique Recombinant Forms (URFs) have previously been identified in France. Here we show that one of them (URF5_B/02/G) is emerging in MSM, a high-risk population where HIV incidence and number of superinfections are increasing. We describe this new Circulating Recombinant Form, CRF56_cpx, estimate the time to its most recent common ancestor, investigate its origins and show that it probably shares common ancestors with strains from the East Mediterranean.

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