Format

Send to

Choose Destination
See comment in PubMed Commons below
J Am Acad Dermatol. 2014 Jan;70(1):55-9. doi: 10.1016/j.jaad.2013.08.034. Epub 2013 Oct 21.

Compliance with pregnancy prevention measures during isotretinoin therapy.

Author information

1
School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
2
Medical student, Loyola University of Chicago School of Medicine, Chicago, Illinois.
3
Division of Dermatology, Department of Internal Medicine, Loyola University of Chicago School of Medicine, Chicago, Illinois.
4
Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania.
5
Department of Internal Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
6
Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: ferrislk@upmc.edu.

Abstract

BACKGROUND:

Approximately 150 women annually become pregnant while taking isotretinoin despite participation in the iPLEDGE program. Noncompliance with the requirement to be abstinent or use 2 contraceptive methods may be a contributing factor.

OBJECTIVE:

We sought to determine the degree of adherence to contraception or abstinence among women taking isotretinoin.

METHODS:

We conducted an anonymous survey of women of childbearing potential taking isotretinoin for at least 2 months.

RESULTS:

Among 75 participants, 21 (28%) chose abstinence as their primary means of pregnancy prevention, of whom 4 (19%) were sexually active during treatment. The most commonly chosen contraceptive methods among the 39 women who were sexually active were condoms (35, 90%) and oral contraceptive pills (18, 46%). Twelve women (31%) admitted to having intercourse at least once using 1 or fewer forms of contraception; 10 failed to use condoms, and 1 reported completely unprotected intercourse. Among sexually active oral contraceptive pill users, 7 (39%) reported missing 1 or more pills in the previous month.

LIMITATIONS:

Data were self-reported, thus participants may have inaccurately reported contraception use.

CONCLUSIONS:

Encouraging the use of highly effective, patient-independent contraception and limiting abstinence to women who have never been sexually active may further reduce the rate of isotretinoin-exposed pregnancies.

KEYWORDS:

acne; condoms; contraception; iPLEDGE; intrauterine device; isotretinoin; oral contraceptive pills

PMID:
24157382
DOI:
10.1016/j.jaad.2013.08.034
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center