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Curr Biol. 2013 Oct 21;23(20):R923-5. doi: 10.1016/j.cub.2013.09.030.

Chromosome biology: Wapl spreads its wings.

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1
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address: hongtao.yu@utsouthwestern.edu.

Abstract

Chromosome segregation requires the removal of cohesion and catenation between sister chromosomes, two physical linkages established during DNA replication. Two new studies reveal that, among other functions, the wings apart-like protein (Wapl) coordinates cohesin removal with decatenation of sister chromosomes during mitosis in mammalian cells.

PMID:
24156811
DOI:
10.1016/j.cub.2013.09.030
[Indexed for MEDLINE]
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