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Comput Methods Biomech Biomed Engin. 2015;18(8):805-15. doi: 10.1080/10255842.2013.847095. Epub 2013 Oct 25.

Validation of numerical flow simulations against in vitro phantom measurements in different type B aortic dissection scenarios.

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a Department of Biomedical Engineering , International Center for Numerical Methods in Engineering (CIMNE), Universitat Politècnica de Catalunya , Barcelona , Spain.


An aortic dissection (AD) is a serious condition defined by the splitting of the arterial wall, thus generating a secondary lumen [the false lumen (FL)]. Its management, treatment and follow-up are clinical challenges due to the progressive aortic dilatation and potentially severe complications during follow-up. It is well known that the direction and rate of dilatation of the artery wall depend on haemodynamic parameters such as the local velocity profiles, intra-luminal pressures and resultant wall stresses. These factors act on the FL and true lumen, triggering remodelling and clinical worsening. In this study, we aimed to validate a computational fluid dynamic (CFD) tool for the haemodynamic characterisation of chronic (type B) ADs. We validated the numerical results, for several dissection geometries, with experimental data obtained from a previous in vitro study performed on idealised dissected physical models. We found a good correlation between CFD simulations and experimental measurements as long as the tear size was large enough so that the effect of the wall compliance was negligible.


aortic diseases; aortic dissection; computational fluid dynamics; in vitro phantoms

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