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Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Oct;21(5):1361-4. doi: 10.7534/j.issn.1009-2137.2013.05.055.

[Mechanism and early evaluation of CNS infiltration in acute lymphocytic leukemia-review].

[Article in Chinese]

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Department of Hematology, Shanghai Ruijin Hospital, Shanghai 200233, China.


Central nervous system (CNS) is one of places in which direct infiltration and involvement or relapse occur in adult lymphocytic leukemia. The main mechanism of CNS infiltration in leukemia is associated with blood brain barrier (BBB), however the ALL CNS infiltration is difficulty early predicted and evaluated.For this reason, the studies on accurately evaluating the ALL CNS infiltration have important significance for early diagnosis and adjustment of therapeutic regimen, performance of individualised treatment and improvement of ALL patient's prognosis. In this article, the pathway of ALL CNS infiltration and its molecular mechanism, the evaluation methods for BBB function are reviewed.

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