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Pancreas. 2013 Nov;42(8):1227-37. doi: 10.1097/MPA.0b013e3182a9ad9d.

Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop.

Author information

1
From the *Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; †Department of Surgery, Karolinska Institute, Stockholm, Sweden; ‡Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology, Barcelona, Spain; §Departments of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; ∥Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN; ¶Department of Epidemiology, Mayo Graduate School of Medicine, Rochester, MN; and #Departments of Medicine, Cell Biology and Physiology, and Human Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Abstract

A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Cancer Institute (NCI) on "Pancreatitis-Diabetes-Pancreatic Cancer" focused on the risk factors of chronic pancreatitis (CP) and diabetes mellitus (DM) on the development of pancreatic ductal adenocarcinoma (PDAC). Sessions were held on (a) an overview of the problem of PDAC; (b) CP as a risk factor of PDAC; (c) DM as a risk factor of PDAC; (d) pancreatogenic, or type 3c, DM; (e) genomic associations of CP, DM, and PDAC; (f) surveillance of high-risk populations and early detection of PDAC; and (g) effects of DM treatment on PDAC. Recent data and current understandings of the mechanisms of CP- and DM-associated factors on PDAC development were discussed, and a detailed review of the possible risks of DM treatment on the development of PDAC was provided by representatives from academia, industry, and the Food and Drug Administration. The current status of possible biomarkers of PDAC and surveillance strategies for high-risk populations were discussed, and the gaps in knowledge and opportunities for further research were elucidated. A broad spectrum of expertise of the speakers and the discussants provided an unusually productive workshop, the highlights of which are summarized in the accompanying article.

PMID:
24152948
PMCID:
PMC3878448
DOI:
10.1097/MPA.0b013e3182a9ad9d
[Indexed for MEDLINE]
Free PMC Article

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