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J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):621-6.

Stress hormones regulate periodontal inflammation.

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1
Department of Periodontology, Tufts University School of Dental Medicine, Boston, USA.

Abstract

Periodontal disease involves inflammation of the gingival tissues, caused by microbial pathogens. Recent papers suggest that emotional stress worsens periodontal disease. Here we review the literature and propose that corticotropin-releasing hormone (CRH) secreted under stress stimulates gingival mast cells together with other neuropeptides and cytokines to secrete pro-inflammatory molecules that contribute to periodontal pathology. Stress reduction and/or mast cell inhibition may provide additional therapeutic approaches.

PMID:
24152831
[Indexed for MEDLINE]
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