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J Biol Chem. 2013 Nov 29;288(48):34287-94. doi: 10.1074/jbc.R113.512517. Epub 2013 Oct 22.

Cross-talk between site-specific transcription factors and DNA methylation states.

Author information

1
From the Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 and.

Abstract

DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. Because DNA methylation is reversible, there is much interest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and distal regulatory elements. Additional in vivo genome-wide characterization of transcription factor binding patterns and high-resolution DNA methylation analyses are clearly required for stronger support of each model.

KEYWORDS:

DNA Methylation; DNA-binding Protein; Epigenetics; Gene Regulation; Transcription Factors

PMID:
24151070
PMCID:
PMC3843044
DOI:
10.1074/jbc.R113.512517
[Indexed for MEDLINE]
Free PMC Article
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