Format

Send to

Choose Destination
J Expo Sci Environ Epidemiol. 2014 Sep-Oct;24(5):459-66. doi: 10.1038/jes.2013.69. Epub 2013 Oct 23.

Personal care product use and urinary phthalate metabolite and paraben concentrations during pregnancy among women from a fertility clinic.

Author information

1
Department of Epidemiology, Program in Public Health, Brown University, Providence, Rhode Island, USA.
2
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
3
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.
4
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Abstract

Parabens and phthalates are potential endocrine disruptors frequently used in personal care/beauty products, and the developing fetus may be sensitive to these chemicals. We measured urinary butyl-paraben (BP), methyl-paraben, propyl-paraben, mono-n-butyl phthalate (MBP), and monoethyl phthalate (MEP) concentrations up to three times in 177 pregnant women from a fertility clinic in Boston, MA. Using linear mixed models, we examined the relationship between self-reported personal care product use in the previous 24 h and urinary paraben and phthalate metabolite concentrations. Lotion, cosmetic, and cologne/perfume use were associated with the greatest increases in the molar sum of phthalate metabolite and paraben concentrations, although the magnitude of individual biomarker increases varied by product used. For example, women who used lotion had BP concentrations 111% higher (95% confidence interval (CI): 41%, 216%) than non-users, whereas their MBP concentrations were only 28% higher (CI: 2%, 62%). Women using cologne/perfume had MEP concentrations 167% (CI: 98%, 261%) higher than non-users, but BP concentrations were similar. We observed a monotonic dose-response relationship between the total number of products used and urinary paraben and phthalate metabolite concentrations. These results suggest that questionnaire data may be useful for assessing exposure to a mixture of chemicals from personal care products during pregnancy.

PMID:
24149971
PMCID:
PMC4016195
DOI:
10.1038/jes.2013.69
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center