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Cardiovasc Intervent Radiol. 2014 Aug;37(4):1027-33. doi: 10.1007/s00270-013-0756-2. Epub 2013 Oct 23.

Stereotactic radiofrequency ablation for liver tumors in inherited metabolic disorders.

Author information

1
Department of Pediatrics I, Inherited Metabolic Disorders, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria, daniela.karall@i-med.ac.at.

Abstract

PURPOSE:

Both glycogen storage disease type Ia (GSD Ia) and tyrosinemia type I (TYR I) are inherited metabolic disorders that can be complicated by formation of liver adenomas in juvenile/young adult age and/or development of hepatocellular carcinoma. We describe the first application of stereotactic radiofrequency ablation (SRFA) in focal lesions in three patients with inherited metabolic disorders affecting the liver.

METHODS:

SRFA was applied for removal of single large liver adenomas in a 22-year-old woman and a 20-year-old man with GSD Ia and of a suspicious lesion in a 16-year-old girl with TYR I with α-fetoprotein (AFP) elevation.

RESULTS:

SRFA was successful. Large scars were avoided, and in the TYR I patient, elevated AFP values promptly returned to normal.

CONCLUSION:

The SRFA technique is a good alternative to surgical resection of focal liver lesions and could greatly help patients with inherited metabolic disorders with liver involvement, including focal liver lesions and potential malignancy.

PMID:
24149831
DOI:
10.1007/s00270-013-0756-2
[Indexed for MEDLINE]

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