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J Cardiovasc Med (Hagerstown). 2013 Dec;14(12):886-93. doi: 10.2459/JCM.0b013e3283644bb2.

Cardiac Resynchronization Therapy MOdular REgistry: ECG and Rx predictors of response to cardiac resynchronization therapy (NCT01573091).

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aClinica Mediterranea, Napoli bUniversità di Padova, Padova cOspedale S'Anna, San Fermo della Battaglia (CO) dOspedale SS Trinità, Cagliari eOspedale Gavazzeni, Bergamo fOspedale Carlo Poma, Mantova gOspedale Sant'Antonio Abate, Gallarate (VA) hClinica San Michele, Maddaloni (CE) iOspedale Monaldi, Napoli jOspedale Poliambulanza, Brescia kOspedale Panico, Tricase (LE) lOspedale Pugliese-Ciaccio, Catanzaro mOspedale SS Giacomo e Cristoforo, Massa nBoston Scientific Italia, Milan oOspedale Careggi, Università di Firenze, Firenze, Italy.



A variable proportion, up to 30%, of patients who undergo cardiac resynchronization therapy (CRT) do not benefit from treatment. The aim of the Cardiac Resynchronization Therapy MOdular REgistry (CRT MORE) is to determine whether specific electrocardiographic and radiographic parameters can be used to predict clinical and echocardiographic response to CRT.


The CRT MORE is a prospective, single-arm, multicenter cohort study designed to evaluate the electrocardiographic and radiographic predictors of response to CRT. All study patients receive a pacemaker or implantable defibrillator for CRT delivery in accordance with current guidelines. Enrollment started in December 2011 and is scheduled to end in November 2013. Approximately 1100 consecutive patients will be enrolled in 30 Italian centers and will be followed up for 60 months after implantation. The primary endpoint is the improvement in clinical (Clinical Composite Score) and echocardiographic (a decrease of ≥ 15% in left ventricular end-systolic volume) parameters at the 6-month follow-up visit.


This study might provide important information about which electrocardiographic and radiographic parameters better predict CRT response.

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