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Multidiscip Respir Med. 2013 Oct 22;8(1):69. doi: 10.1186/2049-6958-8-69.

The maximum standardized FDG uptake on PET-CT in patients with non-small cell lung cancer.

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1
Department of Chest Diseases, Istanbul Medipol University Hospital, Istanbul, Turkey. drekremcs@yahoo.com.

Abstract

BACKGROUND:

Non-small cell lung cancer (NSCLC) accounts for approximately 80% of new diagnoses of pulmonary carcinoma. This study investigated the correlation between 18 F-fluorodeoxyglucose uptake in computerized tomography integrated positron emission tomography and tumor size, lymph node metastasis, and distant metastasis in patients with NSCLC.

METHODS:

The records of 151 NSCLC patients (139 male, 12 female; mean age 59.60 years) were evaluated retrospectively.

RESULTS:

Forty-one cases were adenocarcinomas; 45 squamous cell carcinomas; and 65 unspecified NSCLC. When the cases were categorized according to tumor size (group 1, ≤ 3 cm; group 2, > 3 and ≤ 5 cm; group 3, > 5 cm), the maximum standardized uptake value (SUVmax) was significantly lower in groups 1 and 2 compared with group 3 (p = 0.006 for each). Considering all cases, tumor SUVmax was not correlated with age, gender, or histopathological type. Lymph node metastases were pathologically proven in 24 cases: 24% of these were adenocarcinomas, 6% squamous cell carcinomas, and 16% unspecified NSCLC. Neither lymph node involvement nor distant metastases were correlated with tumor SUVmax, although lymph node size was positively correlated with lymph node SUVmax (r = 0.775; p < 0.001).

CONCLUSIONS:

SUVmax was significantly associated with tumor size, but not with distant metastases or lymph node involvement. Therefore, SUVmax on positron emission tomography is not predictive of the presence of metastases.

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