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Curr Opin Immunol. 2013 Oct;25(5):556-63. doi: 10.1016/j.coi.2013.09.003. Epub 2013 Oct 20.

Lineage relationship of effector and memory T cells.

Author information

1
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: restifo@nih.gov.

Abstract

Adaptive immunity is characterized by the ability to form long-lived immunological memory. Upon re-exposure to antigen, memory T cells respond more rapidly and robustly than naïve T cells, providing better clearance of pathogens. Recent reviews have reinforced the text-book view that memory T cells arise from effector cells. Although this notion is teleologically appealing, emerging data are more consistent with a model where naïve cells directly develop into memory cells without transitioning through an effector stage. A clear understanding of the lineage relationships between memory and effector cells has profound implications for the design of vaccines and for the development of effective T cell-based therapies.

PMID:
24148236
PMCID:
PMC3858177
DOI:
10.1016/j.coi.2013.09.003
[Indexed for MEDLINE]
Free PMC Article

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