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Nutr Rev. 2013 Oct;71 Suppl 1:S42-54. doi: 10.1111/nure.12068.

Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies.

Author information

1
Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico.

Abstract

Maternal obesity can profoundly affect offspring phenotype and predisposition to obesity and metabolic disease. Carefully controlled studies in precocial and altricial mammalian species provide insights into the involved mechanisms. These include programming of hypothalamic appetite-regulating centers to increase orexigenic relative to anorexigenic drive; increasing maternal, fetal, and offspring adrenal and peripheral tissue glucocorticoid production; and increasing maternal oxidative stress. Outcomes often show offspring sex differences that may play a role in the differential susceptibility of males and females to later-life obesity and other related metabolic diseases.

KEYWORDS:

altricial mammalian species; maternal obesity; offspring phenotype; offspring programming mechanisms; precocial mammalian species

PMID:
24147924
DOI:
10.1111/nure.12068
[Indexed for MEDLINE]

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