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Afr J Tradit Complement Altern Med. 2013 Apr 12;10(3):418-21. eCollection 2013.

Quercetin: a potential natural drug for adjuvant treatment of rheumatoid arthritis.

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1
College of Pharmacy, Dalian Medical University, Dalian 116044, China.

Abstract

Rheumatoid arthritis (RA) is the rheumatism mainly manifested as disabling joint disease and mainly involves hands, wrists, feet and other small joints. Recurrent arthritis attacks, synovial cell hypertrophy and hyperplasia and bone and cartilage damages eventually lead to joint dysfunction and other complications, and there is no cure. Quercetin (QU) is a kind of natural flavonoids, with lipid-lowering, anti-inflammatory and other pharmacological activities, and minor toxic side effects. Thus, we assume that QU may be an adjuvant natural drug for treatment of RA. The possible mechanism is through regulation of NF-κB, to inhibit the transcription of joint synovitis factors, hinder the generation of inflammatory factors, and inhibit the inflammatory reaction; through inhibiting the activities of VEGF, bFGF, MMP-2 and other cytokines, to inhibit angiogenesis in multiple links and inhibit synovial pannus formation. QU may be an adjuvant natural drug for treatment of RA.

KEYWORDS:

natural drug; quercetin; rheumatoid arthritis

PMID:
24146468
PMCID:
PMC3777580
[Indexed for MEDLINE]
Free PMC Article
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