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Afr J Tradit Complement Altern Med. 2012 Dec 31;10(2):251-7. eCollection 2013.

Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway.

Author information

1
Institute of Genetic Engineering, Southern Medical University, Tonghe, Guangzhou 510515, P.R. China.

Abstract

In this study, isoegomaketone(IK) was isolated from Perilla frutescens(L.), a Chinese herbal. The effects of IK were examined by cell viability assay, colony formation assay, xenograft tumor assay and western blotting in HCC cells. We found that IK inhibited cell viability, and its administration decreased tumor volume and weight profoundly. The presence of IK(10 nmol/l) produced a dramatic decrease of pAkt, while total Akt level was not affected. The data suggested that IK from perilla suppressed HCC tumor growth via blocking PI3K/Akt signaling pathway.

KEYWORDS:

HCC; IK; PI3K/AKT; Perilla Frutescens; Tumor Proliferation

PMID:
24146448
PMCID:
PMC3746572
[Indexed for MEDLINE]
Free PMC Article

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