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Vet Comp Orthop Traumatol. 2014;27(1):20-6. doi: 10.3415/VCOT-12-11-0139. Epub 2013 Oct 22.

Comparison of meloxicam and a glucosamine-chondroitin supplement in management of feline osteoarthritis. A double-blind randomised, placebo-controlled, prospective trial.

Author information

1
Rui M. Sul, LMV MRCVS, Small Animal Hospital, School of Veterinary Medicine, University of Glasgow, 464 Bearsden Road, Glasgow G61 1QH, United Kingdom, Phone: +44 141 330 5848, Fax: +44 141 330 3663, Email: r.sul.1@research.gla.ac.uk.

Abstract

OBJECTIVE:

To compare the efficacy of meloxicam and a glucosamine-chondroitin (Glu-Ch) supplement in the management of feline osteoarthritis (OA).

METHODS:

Prospective, blinded, randomized clinical trial. Cats over eight years of age with clinical signs of chronic OA were assigned to one of two groups and Glu-Ch or meloxicam was administered orally for 70 days, followed by a placebo until day 98. Cats were assessed by a veterinarian on five occasions and the owner completed an assessment form at the same time.

RESULTS:

Data were collected from thirty cats. Pre-treatment disease scores were significantly higher in the meloxicam group for owner mobility (p=0.01) and veterinary lameness (p=0.02). Owner mobility scores at day 14 (p=0.01) and day 42 (p=0.002) were significantly improved compared to pre-treatment scores for the meloxicam group. When meloxicam and Glu-Ch were discontinued and the placebo commenced, a significant proportion of the meloxicam group showed worsening of all the owner-assessed scores between day 70 and day 98, when compared to the Glu-Ch group (mobility p=0.01; activity p=0.02; temperament p=0.04; lifestyle p=0.01).

CONCLUSIONS:

Treatment with meloxicam resulted in a significant improvement in mobility and activity levels of cats with OA until the placebo was introduced. A greater proportion of cats receiving meloxicam medication showed a significant worsening of owner assessment scores once the placed was introduced, when compared to the Glu-Ch group.

KEYWORDS:

Feline; chondroitin; glucosamine; meloxicam; osteoarthritis

PMID:
24146058
DOI:
10.3415/VCOT-12-11-0139
[Indexed for MEDLINE]

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