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Nat Immunol. 2013 Nov;14(11):1118-1126. doi: 10.1038/ni.2736.

Effect of helminth-induced immunity on infections with microbial pathogens.

Author information

1
Department of Medicine, Center for Emerging Pathogens, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
2
Department of Medicine, Center for Immunity and Inflammation, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
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Contributed equally

Abstract

Helminth infections are ubiquitous worldwide and can trigger potent immune responses that differ from and potentially antagonize host protective responses to microbial pathogens. In this Review we focus on the three main killers in infectious disease-AIDS, tuberculosis and malaria-and critically assesses whether helminths adversely influence host control of these diseases. We also discuss emerging concepts for how M2 macrophages and helminth-modulated dendritic cells can potentially influence the protective immune response to concurrent infections. Finally, we present evidence advocating for more efforts to determine how and to what extent helminths interfere with the successful control of specific concurrent coinfections.

PMID:
24145791
PMCID:
PMC4955540
DOI:
10.1038/ni.2736
[Indexed for MEDLINE]
Free PMC Article

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