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Int J Mol Sci. 2013 Oct 18;14(10):20983-1005. doi: 10.3390/ijms141020983.

Biofilm matrix and its regulation in Pseudomonas aeruginosa.

Author information

1
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, No.3, 1st Beichen West Road, Chaoyang District, Beijing 100101, China. luyanma27@im.ac.cn.

Abstract

Biofilms are communities of microorganisms embedded in extracellular polymeric substances (EPS) matrix. Bacteria in biofilms demonstrate distinct features from their free-living planktonic counterparts, such as different physiology and high resistance to immune system and antibiotics that render biofilm a source of chronic and persistent infections. A deeper understanding of biofilms will ultimately provide insights into the development of alternative treatment for biofilm infections. The opportunistic pathogen Pseudomonas aeruginosa, a model bacterium for biofilm research, is notorious for its ability to cause chronic infections by its high level of drug resistance involving the formation of biofilms. In this review, we summarize recent advances in biofilm formation, focusing on the biofilm matrix and its regulation in P. aeruginosa, aiming to provide resources for the understanding and control of bacterial biofilms.

PMID:
24145749
PMCID:
PMC3821654
DOI:
10.3390/ijms141020983
[Indexed for MEDLINE]
Free PMC Article

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