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Front Neuroendocrinol. 2014 Apr;35(2):171-9. doi: 10.1016/j.yfrne.2013.10.001. Epub 2013 Oct 19.

Corticotropin releasing factor in neuroplasticity.

Author information

1
Departments of Anatomy/Neurobiology, University of California-Irvine, Irvine, CA, USA.
2
Departments of Anatomy/Neurobiology, University of California-Irvine, Irvine, CA, USA; Department of Pediatrics, University of California-Irvine, Irvine, CA, USA. Electronic address: tallie@uci.edu.

Abstract

Stress is among the strongest signals promoting neuroplasticity: Stress signals, indicating real or perceived danger, lead to alterations of neuronal function and often structure, designed to adapt to the changed conditions and promote survival. Corticotropin releasing factor (CRF) is expressed and released in several types of neuronal populations that are involved in cognition, emotion and the regulation of autonomic and endocrine function. CRF expressing neurons undergo functional and structural plasticity during stress and, in addition, the peptide acts via specific receptors to promote plasticity of target neurons.

KEYWORDS:

CRF; Epigenetics; Hippocampus; Hypothalamus; Memory; Neuropeptide; Plasticity; Stress; Synapse

PMID:
24145148
PMCID:
PMC3965598
DOI:
10.1016/j.yfrne.2013.10.001
[Indexed for MEDLINE]
Free PMC Article

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