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Gynecol Oncol. 2013 Dec;131(3):701-7. doi: 10.1016/j.ygyno.2013.10.014. Epub 2013 Oct 19.

A novel diagnostic criterion for lymph node metastasis in cervical cancer using multi-detector computed tomography.

Author information

1
Department of Gynecology and Obstetrics, Kyoto University, Graduate School of Medicine, Japan.

Abstract

OBJECTIVES:

The sensitivity of the current 10mm cut-off diameter that is used to diagnose lymph node (LN) metastasis is too low. This is the first study to develop a new criterion to diagnose LN metastasis in a region-by-region manner using multi-detector computed tomography (MDCT).

METHODS:

1) The short-axis diameter of the LNs in MDCT images from 1-mm slices obtained immediately prior to surgery was compared with the pathological diagnosis in 78 uterine cervical cancer patients undergoing primary surgery. For the region-by-region analysis, we divided para-aortic and pelvic spaces into 13 regions. 2) In 28 cases in which patients received neoadjuvant chemotherapy (NAC) followed by surgery, we compared MDCT images before and after NAC.

RESULTS:

1) The optimal cut-off in the region-by-region analysis was 5mm, yielding 71% sensitivity and 79% specificity. 2) NAC significantly decreased LN size (p<0.0001). NAC decreased the number of swollen LN regions (>5mm) from 51% (81/158) to 26% (41/158).

CONCLUSIONS:

The new criterion developed using MDCT could be effective for accurately assessing LN status. It also facilitates the assessment of NAC efficacy regarding the eradication of LN metastases.

KEYWORDS:

Cervical cancer; Lymph node metastasis; Multi-detector computed tomography (MDCT); Neoadjuvant chemotherapy (NAC)

PMID:
24145112
DOI:
10.1016/j.ygyno.2013.10.014
[Indexed for MEDLINE]
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