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Neurosci Res. 2014 Feb;79:1-12. doi: 10.1016/j.neures.2013.10.004. Epub 2013 Oct 19.

Neuroinflammation: the role and consequences.

Author information

1
Section of Anaesthetics, Pain Medicine & Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.
2
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
3
Section of Anaesthetics, Pain Medicine & Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK. Electronic address: d.ma@imperial.ac.uk.

Abstract

Neuroinflammation is central to the common pathology of several acute and chronic brain diseases. This review examines the consequences of excessive and prolonged neuroinflammation, particularly its damaging effects on cellular and/or brain function, as well as its relevance to disease progression and possible interventions. The evidence gathered here indicates that neuroinflammation causes and accelerates long-term neurodegenerative disease, playing a central role in the very early development of chronic conditions including dementia. The wide scope and numerous complexities of neuroinflammation suggest that combinations of different preventative and therapeutic approaches may be efficacious.

KEYWORDS:

Alzheimer's disease; Microglia; Multiple sclerosis; Neuroinflammation; Postoperative cognitive dysfunction; Systemic inflammation

PMID:
24144733
DOI:
10.1016/j.neures.2013.10.004
[Indexed for MEDLINE]

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