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Langmuir. 2014 Feb 18;30(6):1473-88. doi: 10.1021/la403220p. Epub 2013 Nov 8.

Droplet microfluidics for producing functional microparticles.

Author information

1
Department of Chemical and Biomolecular Engineering and ‡National Creative Research Initiative Center for Integrated Optofluidic Systems, KAIST , Daejeon 305-701, South Korea.

Abstract

Isotropic microparticles prepared from a suspension that undergoes polymerization have long been used for a variety of applications. Bulk emulsification procedures produce polydisperse emulsion droplets that are transformed into spherical microparticles through chemical or physical consolidation. Recent advances in droplet microfluidics have enabled the production of monodisperse emulsions that yield highly uniform microparticles, albeit only on a drop-by-drop basis. In addition, microfluidic devices have provided a variety of means for particle functionalization through shaping, compartmentalizing, and microstructuring. These functionalized particles have significant potential for practical applications as a new class of colloidal materials. This feature article describes the current state of the art in the microfluidic-based synthesis of monodisperse functional microparticles. The three main sections of this feature article discuss the formation of isotropic microparticles, engineered microparticles, and hybrid microparticles. The complexities of the shape, compartment, and microstructure of these microparticles increase systematically from the isotropic to the hybrid types. Each section discusses the key idea underlying the design of the particles, their functionalities, and their applications. Finally, we outline the current limitations and future perspectives on microfluidic techniques used to produce microparticles.

PMID:
24143936
DOI:
10.1021/la403220p

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