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Inorg Chem. 2014 Feb 17;53(4):1900-15. doi: 10.1021/ic401587r. Epub 2013 Oct 21.

Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold.

Author information

1
Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

Abstract

Acidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO2, and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.

PMID:
24143874
PMCID:
PMC3944830
DOI:
10.1021/ic401587r
[Indexed for MEDLINE]
Free PMC Article

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