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Clin Endosc. 2013 Sep;46(5):572-5. doi: 10.5946/ce.2013.46.5.572. Epub 2013 Sep 30.

Gastrointestinal cancers in a peutz-jeghers syndrome family: a case report.

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Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.


A 17-year-old man was diagnosed as Peutz-Jeghers syndrome (PJS) because of pigmented lip and multiple gastrointestinal polyps. He had anemia and underwent polypectomy on the duodenum and colon. His maternal family members were patients with PJS. His mother used to be screened with endoscopy to remove large polyps. One and half years later, he underwent jejunal segmental resection due to intussusceptions. He underwent endoscopic polypectomy every 2 to 3 years. When he was 23 years old, high-grade dysplasia was found in colonic polyp and his mother underwent partial pancreatectomy due to intraductal papillary mucinous carcinoma. When he was 27 years old, diffuse gastric polyps on the greater curvature of corpus expanded and grew. Therefore, wide endoscopic polypectomy was done. Histological examination revealed focal intramucosal carcinoma and low-grade dysplasia in hamartomatous polyps. We report cases of cancers occurred in first-degree relatives with PJS.


Pancreatic neoplasms; Peutz-Jeghers syndrome; Stomach neoplasms

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