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J Pediatr (Rio J). 2014 Jan-Feb;90(1):28-34. doi: 10.1016/j.jped.2013.06.006. Epub 2013 Oct 16.

Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: a triple-masked controlled trial.

Author information

  • 1Pediatrics Department, Child Growth and Development Research Center and Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: kelishadi@med.mui.ac.ir.
  • 2Pediatrics Department, Child Growth and Development Research Center and Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • 3Department of English Linguistics, University of Isfahan, Isfahan, Iran.

Abstract

OBJECTIVE:

This triple-masked controlled trial aimed to assess the effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in obese children and adolescents.

METHODS:

The study comprised 50 participants, aged 10 to 16 years, who were randomly assigned into two groups of equal number. In this 12-week trial, one group received oral vitamin D (300,000 IU) and the other group received placebo. Cardiometabolic risk factors, insulin resistance, and a continuous value of metabolic syndrome (cMetS) were determined. Statistical analysis was conducted after adjustment for covariate interactions.

RESULTS:

Overall, 21 patients in the vitamin D group and 22 in the placebo group completed the trial. No significant difference was observed in the baseline characteristics of the two groups. After the trial, in the vitamin D group, serum insulin and triglyceride concentrations, as well as HOM -IR and C-MetS decreased significantly, both when compared with the baseline and with the placebo group. No significant difference was observed when comparing total cholesterol, LDL-C, HDL-C, fasting blood glucose, and blood pressure.

CONCLUSION:

The present findings support the favorable effects of vitamin D supplementation on reducing insulin resistance and cardiometabolic risk factors in obese children.

KEYWORDS:

Children and adolescents; Crianças e adolescentes; Insulin resistance; Metabolic syndrome; Resistência à insulina; Síndrome metabólica; Vitamin D; Vitamina D

PMID:
24140383
DOI:
10.1016/j.jped.2013.06.006
[PubMed - indexed for MEDLINE]
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