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Ann Thorac Surg. 2014 Jan;97(1):29-36. doi: 10.1016/j.athoracsur.2013.07.100. Epub 2013 Oct 17.

Clinical results of transcatheter aortic valve implantation in octogenarians and nonagenarians: insights from the FRANCE-2 registry.

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Centre Hospitalier Universitaire (CHU)-Henri Mondor, Creteil, France. Electronic address:
Centre Hospitalier Universitaire (CHU)-Henri Mondor, Creteil, France.
CHU-Brest, Brest, France.
CHU-Dupuytren, Limoges, France.
Hopital Charles Nicolle, University of Rouen, INSERM Unite 1096, Rouen, France.
Clinique Pasteur, Toulouse, France.
Bichat Hospital, Paris, France.
Insitut Jacques Cartier, Massy, France.
Pitie-Salpetriere Hospital, Paris, France.
CHU-Rennes, Rennes, France.
CHU-Lille, Lille, France.
University Lyon 1, Lyon, France.



Although transcatheter aortic valve implantation has been developing as an alternative treatment in elderly patients with high surgical risk, age-specific differences in clinical outcome have not been fully validated.


Data were analyzed for 2,254 patients at least 80 years old who were enrolled between January 2010 and October 2011 in the French national transcatheter aortic valve implantation registry, FRANCE-2. Procedural and clinical outcomes defined according to the Valve Academic Research Consortium criteria were compared among subjects in three age groups: 80 to 84 years (n = 867), 85 to 89 years (n = 1,064), and at least 90 years (n = 349; range, 90 to 101 years).


The self-expandable prosthesis was implanted in 710 patients, and the balloon-expandable prosthesis was implanted in 1,544 patients. No differences were observed in rates of procedural success, Valve Academic Research Consortium-defined complications, and length of hospitalization among groups. Cumulative 30-day mortalities did not change among the three groups (80 to 84 years, 10.3% versus 85 to 89 years, 9.5% versus ≥ 90 years, 11.2%; p = 0.53). Cumulative 1-year mortalities also showed no statistical differences, although the mortality rate was higher in patients 85 to 89 years old and at least 90 years old compared with those 80 to 84 years old (19.8% versus 26.1% versus 27.7%; p = 0.16). After adjustment for differential baseline characteristics and potential confounders, patient age (85 to 89 years and ≥ 90 years compared with 80 to 84 years) was not associated with increasing risk of 30-day mortality (hazard ratio, 0.92, 1.26; 95% confidence interval, 0.66 to 1.27, 0.83 to 1.94; p = 0.38, 0.28, respectively) and 1-year mortality (hazard ratio, 1.16, 1.36; 95% confidence interval, 0.90 to 1.49, 0.97 to 1.89; p = 0.25, 0.073, respectively).


This study revealed acceptable clinical results of transcatheter aortic valve implantation even in very elderly populations.



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