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Trends Endocrinol Metab. 2014 Jan;25(1):42-52. doi: 10.1016/j.tem.2013.09.002. Epub 2013 Oct 18.

Ketone bodies as signaling metabolites.

Author information

1
Gladstone Institutes and University of California San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
2
Gladstone Institutes and University of California San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA. Electronic address: everdin@gladstone.ucsf.edu.

Abstract

Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link the environment, in this case the diet, and gene expression via chromatin modifications. We review the regulation and functions of ketone bodies, the relationship between ketone bodies and calorie restriction, and the implications of HDAC inhibition by the ketone body βOHB in the modulation of metabolism and in diseases of aging.

KEYWORDS:

HDAC; acetylation; calorie restriction; epigenetics; longevity

PMID:
24140022
PMCID:
PMC4176946
DOI:
10.1016/j.tem.2013.09.002
[Indexed for MEDLINE]
Free PMC Article

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