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Bioanalysis. 2013 Oct;5(20):2567-80. doi: 10.4155/bio.13.196.

Recent developments in microfluidic chip-based separation devices coupled to MS for bioanalysis.

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1
Department of Chemistry, Soochow University, No. 70, Linhsi Road, Shihlin, 11102 Taipei, Taiwan.

Abstract

In recent years, the development of microfluidic chip separation devices coupled to MS has dramatically increased for high-throughput bioanalysis. In this review, advances in different types of microfluidic chip separation devices, such as electrophoresis- and LC-based microchips, as well as 2D design of microfluidic chip-based separation devices will be discussed. In addition, the utilization of chip-based separation devices coupled to MS for analyzing peptides/proteins, glycans, drug metabolites and biomarkers for various bioanalytical applications will be evaluated.

PMID:
24138628
DOI:
10.4155/bio.13.196
[Indexed for MEDLINE]
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