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Front Cell Infect Microbiol. 2013 Sep 30;3:54. doi: 10.3389/fcimb.2013.00054. eCollection 2013.

Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms.

Author information

1
Laboratorio de Biología Celular y Molecular, Facultad de Ciencias Médicas, Instituto de Histología y Embriología-CONICET, Universidad Nacional de Cuyo Mendoza, Argentina.

Abstract

Autophagy is involved in several physiological and pathological processes. One of the key roles of the autophagic pathway is to participate in the first line of defense against the invasion of pathogens, as part of the innate immune response. Targeting of intracellular bacteria by the autophagic machinery, either in the cytoplasm or within vacuolar compartments, helps to control bacterial proliferation in the host cell, controlling also the spreading of the infection. In this review we will describe the means used by diverse bacterial pathogens to survive intracellularly and how they are recognized by the autophagic molecular machinery, as well as the mechanisms used to avoid autophagic clearance.

KEYWORDS:

autophagy; intracellular pathogens; phagocytosis; recognition; xenophagy

PMID:
24137567
PMCID:
PMC3786225
DOI:
10.3389/fcimb.2013.00054
[Indexed for MEDLINE]
Free PMC Article

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