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J Pediatr Hematol Oncol. 2014 Mar;36(2):e105-8. doi: 10.1097/MPH.0000000000000006.

Radiation-induced gliomas in 2 pediatric patients with neurofibromatosis type 1: case study and summary of the literature.

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1
Departments of *Neuro-Oncology †Radiology, Children's Hospital Colorado, Aurora ‡Department of Radiation Oncology, University of Colorado, Denver, CO.

Abstract

Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes patients to the formation of sporadic tumors and also increases the risk of radiation-induced malignancies. The most commonly described radiation-induced tumor in NF1 patients is a malignant peripheral nerve sheath tumor. We present 2 children with NF1 who received radiation therapy and subsequently developed high-grade gliomas. We then review the current literature on radiation-induced tumors in NF1 patients. Although radiation may be the most appropriate therapy in specific situations for children with NF1, the secondary tumor risk should be carefully considered.

PMID:
24136023
DOI:
10.1097/MPH.0000000000000006
[Indexed for MEDLINE]
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