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Cancer Cell. 2013 Oct 14;24(4):407-9. doi: 10.1016/j.ccr.2013.10.001.

Cancer-associated osteoclast differentiation takes a good look in the miR(NA)ror.

Author information

1
Division of Endocrinology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.

Abstract

Tumor-bone cell interactions are critical for the development of metastasis-related osteolytic bone destruction. In this issue of Cancer Cell, Ell and colleagues show how a discrete miRNA network regulates osteoclastogenesis during breast cancer bone metastasis. A signature of upregulated miRNAs may have diagnostic and therapeutic implications for bone metastases.

PMID:
24135278
PMCID:
PMC3897244
DOI:
10.1016/j.ccr.2013.10.001
[Indexed for MEDLINE]
Free PMC Article

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