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Neurotherapeutics. 2013 Oct;10(4):647-63. doi: 10.1007/s13311-013-0229-y.

Epigenetics components of aging in the central nervous system.

Author information

1
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA, 94945-1400, USA.

Abstract

This review highlights recent discoveries that have shaped the emerging viewpoints in the field of epigenetic influences in the central nervous system (CNS), focusing on the following questions: (i) How is the CNS shaped during development when precursor cells transition into morphologically and molecularly distinct cell types, and is this event driven by epigenetic alterations?; ii) How do epigenetic pathways control CNS function?; (iii) What happens to "epigenetic memory" during aging processes, and do these alterations cause CNS dysfunction?; (iv) Can one restore normal CNS function by manipulating the epigenome using pharmacologic agents, and will this ameliorate aging-related neurodegeneration? These and other still unanswered questions remain critical to understanding the impact of multifaceted epigenetic machinery on the age-related dysfunction of CNS.

PMID:
24132650
PMCID:
PMC3805869
DOI:
10.1007/s13311-013-0229-y
[Indexed for MEDLINE]
Free PMC Article

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