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Nat Rev Cancer. 2013 Nov;13(11):772-87. doi: 10.1038/nrc3612. Epub 2013 Oct 17.

Tyrosine kinase gene rearrangements in epithelial malignancies.

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1
Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.

Abstract

Chromosomal rearrangements that lead to oncogenic kinase activation are observed in many epithelial cancers. These cancers express activated fusion kinases that drive the initiation and progression of malignancy, and often have a considerable response to small-molecule kinase inhibitors, which validates these fusion kinases as 'druggable' targets. In this Review, we examine the aetiologic, pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases, including anaplastic lymphoma kinase (ALK), ROS1 and RET. We discuss the clinical outcomes with targeted therapies and explore strategies to discover additional kinases that are activated by chromosomal rearrangements in solid tumours.

PMID:
24132104
PMCID:
PMC3902129
DOI:
10.1038/nrc3612
[Indexed for MEDLINE]
Free PMC Article
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