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Hypertens Pregnancy. 2014 Feb;33(1):93-101. doi: 10.3109/10641955.2013.846367. Epub 2013 Oct 16.

Placental transfer of intravenous nicardipine and disposition into breast milk during the control of hypertension in women with pre-eclampsia.

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1
Saitama Medical Center, Department of Obstetrics and Gynecology, Saitama Medical University , Saitama , Japan .

Abstract

OBJECTIVE:

To assess nicardipine safety for fetuses and neonates.

METHODS:

Nicardipine was measured in maternal plasma (MP), umbilical cord arterial (UaP) and venous (UvP) plasma and breast milk (BrM) of 18 women with severe preeclampsia.

RESULTS:

Nicardipine was infused for a mean 11.9 ± 10.5 days before and 4.6 ± 1.6 days after delivery. Nicardipine dose and MP concentration were linearly correlated, as were MP with UaP, UvP, and BrM concentrations. The BrM/MP ratio was 0.06 to 0.30. The mean relative infant dose was 0.082%.

CONCLUSION:

Nicardipine is safe for fetuses and neonates due to its low levels of placental transfer and disposition in BrM.

PMID:
24131296
DOI:
10.3109/10641955.2013.846367
[Indexed for MEDLINE]
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