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J Clin Exp Neuropsychol. 2013;35(9):993-1005. doi: 10.1080/13803395.2013.844773. Epub 2013 Oct 17.

Neuroimaging correlates of everyday action in dementia.

Author information

1
a Department of Psychology , Temple University , Philadelphia , PA , USA.

Abstract

The everyday, functional impairments associated with dementia remain poorly understood from a neuropsychological perspective. This study investigated relations between brain structure volumes and two measures of everyday action-caregiver questionnaire and direct assessment-in 57 participants with dementia. Results showed that caregiver ratings reflecting more functional impairment were strongly associated with smaller volumes of deep white matter. Direct assessment of everyday task performance in a subsample revealed relations between unique neurological substrates and discrete everyday action error types. Findings emphasize differences in functional assessment methods and highlight the role of white matter in functional deficits in dementia.

PMID:
24131088
PMCID:
PMC3882061
DOI:
10.1080/13803395.2013.844773
[Indexed for MEDLINE]
Free PMC Article

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