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Biotechnol Lett. 2014 Mar;36(3):461-9. doi: 10.1007/s10529-013-1382-4. Epub 2013 Oct 16.

Lectin of Abelmoschus esculentus (okra) promotes selective antitumor effects in human breast cancer cells.

Author information

1
Laboratório de Biotecnologia Vegetal e Proteômica, Núcleo de Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, P.O. Box 354, Pelotas, RS, 96010-900, Brazil.

Abstract

The anti-tumor effects of a newly-discovered lectin, isolated from okra, Abelmoschus esculentus (AEL), were investigated in human breast cancer (MCF7) and skin fibroblast (CCD-1059 sk) cells. AEL induced significant cell growth inhibition (63 %) in MCF7 cells. The expression of pro-apoptotic caspase-3, caspase-9, and p21 genes was increased in MCF7 cells treated with AEL, compared to those treated with controls. In addition, AEL treatment increased the Bax/Bcl-2 ratio in MCF7 cells. Flow cytometry also indicated that cell death (72 %) predominantly occurred through apoptosis. Thus, AEL in its native form promotes selective antitumor effects in human breast cancer cells and may represent a potential therapeutic to combat human breast cancer.

PMID:
24129958
DOI:
10.1007/s10529-013-1382-4
[Indexed for MEDLINE]

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