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J Neurovirol. 2013 Dec;19(6):601-5. doi: 10.1007/s13365-013-0213-7. Epub 2013 Oct 16.

Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder.

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1
Hawaii Center for AIDS, University of Hawaii, Honolulu, HI, USA, beau_nakamoto@yahoo.com.

Abstract

We assessed ferumoxytol-enhanced brain MRI to identify monocyte/macrophage accumulation in HIV-associated neurocognitive disorder (HAND). Four HIV-infected subjects with undetectable HIV RNA levels on antiretroviral therapy, HIV DNA level in CD14+ cells ≥10 copies/10(6) cells, and cognitive impairment underwent ferumoxytol-enhanced brain MRI. On post-ferumoxytol susceptibility-weighted images, all HIV-infected subjects demonstrated a diffuse "tram track" appearance in the perivascular regions of cortical and deep white matter vessels suggesting ferumoxytol uptake in monocytes/macrophages. This finding was not present in an HIV-seronegative control. While ferumoxytol may have potential as an imaging biomarker for monocyte/macrophage accumulation in patients with HAND, future study is needed.

PMID:
24129909
PMCID:
PMC3947641
DOI:
10.1007/s13365-013-0213-7
[Indexed for MEDLINE]
Free PMC Article
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