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Brain Struct Funct. 2015 Jan;220(1):193-203. doi: 10.1007/s00429-013-0645-0. Epub 2013 Oct 16.

The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes.

Author information

1
Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany.

Abstract

Sulforhodamine 101 (SR101) is widely used for astrocyte identification, though the labeling mechanism remains unknown and the efficacy of labeling in different brain regions is heterogeneous. By combining region-specific isolation of astrocytes followed by transcriptome analysis, two-photon excitation microscopy, and mouse genetics, we identified the thyroid hormone transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex.

PMID:
24129767
PMCID:
PMC4286632
DOI:
10.1007/s00429-013-0645-0
[Indexed for MEDLINE]
Free PMC Article

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