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J Infect Dev Ctries. 2013 Oct 15;7(10):707-12. doi: 10.3855/jidc.2967.

Increasing incidence of Gram-negative organisms in bacterial agents isolated from diabetic foot ulcers.

Author information

1
Gata Haydarpasa Training Hospital, Istanbul, Turkey. vedatturhan@yahoo.com.

Abstract

INTRODUCTION:

In the present study, we sought to identify the bacterial organisms associated with diabetic foot infections (DFIs) and their antibiotic sensitivity profiles.

METHODOLOGY:

We retrospectively reviewed the records of wound cultures collected from diabetic patients with foot infections between May 2005 and July 2010.

RESULTS:

We identified a total of 298 culture specimens (165 [55%] wound swab, 108 [36%] tissue samples, and 25 [9%] bone samples) from 107 patients (74 [69%] males and 33 [31%] females, mean age 62 ± 13 yr) with a DFI. Among all cultures 83.5% (223/267) were monomicrobial and 16.4% (44/267) were polymicrobial. Gram-negative bacterial isolates (n = 191; 61.3%) significantly outnumbered Gram-positive isolates (n = 121; 38.7%). The most frequently isolated bacteria were Pseudomonas species (29.8%), Staphylococcus aureus (16.7%), Enterococcus species (11.5%), Escherichia coli (7.1%), and Enterobacter species (7.1%), respectively. While 13.2% of the Gram-negative isolates were inducible beta-lactamase positive, 44.2% of Staphylococcus aureus isolates were methicillin resistant.

CONCLUSIONS:

Our results support the recent view that Gram-negative organisms, depending on the geographical location, may predominate in DFIs.

PMID:
24129622
DOI:
10.3855/jidc.2967
[Indexed for MEDLINE]
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