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Arch Pharm Res. 2013 Nov;36(11):1279-90. doi: 10.1007/s12272-013-0238-8. Epub 2013 Oct 16.

Antidepressants for neuro-regeneration: from depression to Alzheimer's disease.

Author information

1
Laboratory of Molecular and Stem Cell Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea, hyunjungkim@cau.ac.kr.

Abstract

Recently identified new potential functions of antidepressants in the treatment of neurodegenerative will be introduced. Antidepressants are reported to regulate stem cell fate to regenerate neurons in the adult hippocampus and are effective in reducing toxic amyloid peptides and are known to increase neurotrophic factor such as brain-derived neurotrophic factor. Clinical trial data support that antidepressants have potential to treat Alzheimer's disease.

PMID:
24129616
DOI:
10.1007/s12272-013-0238-8
[Indexed for MEDLINE]

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