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Eur J Endocrinol. 2013 Nov 22;170(1):63-7. doi: 10.1530/EJE-13-0455. Print 2014 Jan.

The relationship between circulating estradiol and thyroid autoimmunity in males.

Author information

1
Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine.

Abstract

INTRODUCTION:

Although autoimmune thyroid disease is less common in males, it is unclear whether estrogen contributes to the difference in susceptibility among males.

OBJECTIVE:

To examine whether circulating estradiol (E₂) is related to thyroid autoimmunity in males.

PATIENTS AND METHODS:

One-thousand two-hundred and sixty-three males aged 15-94 years were studied. Serum levels of E₂, TSH receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), free thyroxine (FT₄), and TSH were measured by ELISA.

RESULTS:

Circulating E₂ varied widely in males, ranging 18.4-403.7 pmol/l with a mean value of 136.2±51.7 pmol/l. E₂ increased with age (r=0.18, P<0.001). No relationship between E₂ and BMI was found. When comparing the difference in E₂ according to the test results of TRAb, TPOAb, and TgAb, it was found that E₂ was significantly higher in subjects with positive TRAb (TRAb positive, E₂=170.3±59.8 pmol/l; TRAb negative, E₂=134.0±50.6 pmol/l; P<0.001). No difference in E₂ was demonstrated according to the results of TPOAb or TgAb. Logistic regression analysis showed that E₂ was a determinant of positive TRAb, independent of age and BMI. There was no relationship between serum E₂ and TSH or FT₄. However, E₂ was negatively related to TSH (r=-0.45, P<0.01) in subjects whose TSH levels fell below the reference range (0.3-4.2 mIU/l).

CONCLUSION:

Higher circulating E₂ is related to thyroid autoimmunity in males as reflected by positive TRAb.

PMID:
24128431
DOI:
10.1530/EJE-13-0455
[Indexed for MEDLINE]

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