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J Intern Med. 2013 Nov;274(5):451-6. doi: 10.1111/joim.12094.

Public health genomics and personalized prevention: lessons from the COGS project.

Author information

1
Department of Applied Health Research, University College London, London, UK.

Abstract

Using the principles of public health genomics, we examined the opportunities and challenges of implementing personalized prevention programmes for cancer at the population level. Our model-based estimates indicate that polygenic risk stratification can potentially improve the effectiveness and cost-effectiveness of screening programmes. However, compared with 'one-size-fits-all' screening programmes, personalized screening adds further layers of complexity to the organization of screening services and raises ethical, legal and social challenges. Before polygenic inheritance is translated into population screening strategy, evidence from empirical research and engagement with and education of the public and the health professionals are needed.

KEYWORDS:

ethical; legal and social issues; personalized prevention; polygenic risk stratification; public health genomics; screening

PMID:
24127941
PMCID:
PMC4283043
DOI:
10.1111/joim.12094
[Indexed for MEDLINE]
Free PMC Article

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