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J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):189-98. doi: 10.1093/gerona/glt148. Epub 2013 Oct 14.

Age, comorbidities, and AIDS predict a frailty phenotype in men who have sex with men.

Author information

1
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St., Rm E7142, Baltimore, MD 21205. kalthoff@jhsph.edu.

Abstract

BACKGROUND:

Adults aging with HIV infection are at risk for age-related comorbidities and syndromes, such as frailty. The objective of this study was to evaluate the expression and predictors of the frailty phenotype (FP) among HIV-infected (HIV+) and HIV-uninfected (HIV-) men who have sex with men.

METHODS:

A prospective, observational cohort study was nested in the Multicenter AIDS Cohort Study from October 2007-September 2011. FP conversion was defined as the onset of FP over two consecutive study visits. Adjusted odds ratios and 95% confidence intervals ([,]) for FP conversion were estimated using logistic regression models with generalized estimating equations.

RESULTS:

Of 10,571 completed study visits from 1,946 men who have sex with men, 12% and 9% were FP+ among HIV+ and HIV- men, respectively (p = .002). The proportion of FP+ visits increased with age regardless of HIV status, but was significantly greater in HIV+ compared to HIV- men aged 50-64 years. Of the 10,276 consecutive visit pairs contributed by participants, 5% (537) were classified as FP conversion, and 45% of the men with FP conversion had only one FP+ study visit. FP conversion was significantly associated with a history of AIDS (adjusted odds ratios = 2.26 [1.50, 3.39], but not with HIV+ alone (adjusted odds ratios = 1.26 [0.98, 1.64]). Among men who had one or more FP+ visits, 34% of HIV+ and 38% of HIV- men had less than two comorbidities.

CONCLUSIONS:

These findings suggest that expression of the FP can be measured in men who have sex with men with and without HIV infection and reflects multisystem dysfunction in this population; further investigations are needed to better understand clinical utility.

KEYWORDS:

Epidemiology; Frailty; Multimorbidities.

PMID:
24127428
PMCID:
PMC4038242
DOI:
10.1093/gerona/glt148
[Indexed for MEDLINE]
Free PMC Article
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