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J Clin Sleep Med. 2013 Oct 15;9(10):989-93. doi: 10.5664/jcsm.3064.

Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea.

Author information

1
Division of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA ; Arizona Respiratory Center, University of Arizona, Tucson, AZ.

Abstract

STUDY OBJECTIVE:

To determine the impact of continuous positive airway pressure (CPAP) on weight change in persons with obstructive sleep apnea (OSA).

DESIGN SETTING AND PARTICIPANTS:

The Apnea Positive Pressure Long-term Efficacy Study (APPLES) was a 6-month, randomized, double-blinded sham-controlled multicenter clinical trial conducted at 5 sites in the United States. Of 1,105 participants with an apnea hypopnea index ≥ 10 events/ hour initially randomized, 812 had body weight measured at baseline and after 6 months of study.

INTERVENTION:

CPAP or Sham CPAP.

MEASUREMENTS:

Body weight, height, hours of CPAP or Sham CPAP use, Epworth Sleepiness Scale score.

RESULTS:

Participants randomized to CPAP gained 0.35 ± 5.01 kg, whereas those on Sham CPAP lost 0.70 ± 4.03 kg (mean ± SD, p = 0.001). Amount of weight gain with CPAP was related to hours of device adherence, with each hour per night of use predicting a 0.42 kg increase in weight. This association was not noted in the Sham CPAP group. CPAP participants who used their device ≥ 4 h per night on ≥ 70% of nights gained the most weight over 6 months in comparison to non-adherent CPAP participants (1.0 ± 5.3 vs. -0.3 ± 5.0 kg, p = 0.014).

CONCLUSIONS:

OSA patients using CPAP may gain a modest amount of weight with the greatest weight gain found in those most compliant with CPAP.

COMMENTARY:

A commentary on this article appears in this issue on page 995.

CITATION:

Quan SF; Budhiraja R; Clarke DP; Goodwin JL; Gottlieb DJ; Nichols DA; Simon RD; Smith TW; Walsh JK; Kushida CA. Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea.

KEYWORDS:

Continuous positive airway pressure; obstructive sleep apnea; weight

PMID:
24127141
PMCID:
PMC3778188
DOI:
10.5664/jcsm.3064
[Indexed for MEDLINE]
Free PMC Article

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